Effect of the Sequential Administration of Two Doses of Furosemide on Exercise-Induced Pulmonary Hypertension in Thoroughbred Horses

Compared with a single 250-mg dose of furosemide given intravenously 4 h prior to exercise, the administration of two sequential intravenous doses of furosemide (4 and 2 h prior to exercise) does not cause further attenuation of exercise-induced pulmonary capillary hypertension in Thoroughbred horses exercising at their maximal heart rate. Therefore, the sequential administration of two doses of furosemide may not affect the incidence or severity of exercise-induced pulmonary hemorrhage more than the administration of a single dose of furosemide. Authors’ address: Depts. of Veterinary Clinical Medicine (Goetz) and Veterinary Biosciences (Manohar), University of Illinois at UrbanaChampaign, 1008 W. Hazelwood Dr., Urbana, IL 61802. r 1998 AAEP.